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se findings may inform EOLC planning and policy-making and facilitate greater well-being at end-of-life. Disturbed flow induces endothelial dysfunction and contributes to uneven distribution of atherosclerotic plaque. Emerging evidence suggests that harmine, a natural constituent of extracts of Peganum harmala, has potent beneficial activities. Here, we investigated if harmine has an atheroprotective role under disturbed flow and the underlying mechanism. Mice of ApoE , LDLR , and endothelial cell (EC)-specific overexpression of yes-ass
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