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The forced swimming and forced tail suspension time were considerably prolonged, and inflammatory factors IL-1β had been dramatically increased into the hippocampus. Aerobic workout dramatically improves CUMS-depressed mice hippocampal function, efficiently lowering depressive behavior and IL-1β levels, and increasing IL-10 amounts. Besides, aerobic exercise dramatically upregulates the expression level of miR-223 and inhibits the large appearance of TLR4, MyD8
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