https://www.selleckchem.com/pr....oducts/Rapamycin.htm
Even if studied in the exact same artery EDH-type dilation exhibits distinct features in vitro and in vivo in isometrically mounted vessels, it is rather weak and depends on myoendothelial coupling through connexin40 (Cx4, whereas in vivo as well as in vitro under isobaric conditions it is powerful and independent of myoendothelial coupling through Cx40. It is concluded that EDH-type dilations are distinct and a significant dependence on myoendothelial coupling in vitro does not reflect the situation under physiologic conditions in
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