https://www.selleckchem.com/Caspase.html
PURPOSE DNA damage response and repair (DDR) gene alterations are associated with increased tumor infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TM in cancer. Whether DDR alterations are associated with clinical outcomes to PD-(L)1 blockade in non-small cell lung cancer (NSCLC) is unknown. EXPERIMENTAL DESIGN Tumors from patients treated with PD-(L)1 inhibitors were analyzed using targeted next-generation sequencing (NGS). Cancers were categorized based on the presence or absence of deleterious mutati
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