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For kynurenin these concentrations were so high, it complicated the calculation of a transfer ratio for the exogenously administered compound. After 180min of exposure the extent of placental transfer differs substantially for the solutes studied, reflecting different transfer rates. Future studies should investigate to what extent specific uremic solutes reach the fetal circulation in vivo and how they may interfere with organ function and development of the unborn child. After 180 min of exposure the extent of placental transfer differs
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