https://www.selleckchem.com/pr....oducts/evobrutinib.h
While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it is significantly influenced by loading conditions. We hypothesized that global myocardial work index (GMWI), a novel marker of LV function, may show better correlation with load-independent markers of LV contractility in rat models of pressure-induced or volume overload-induced heart failure. Male Wistar rats underwent either transverse aortic constriction (TAC; n=12) or aortocaval fistula creation (ACF; n=12), inducin
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