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Our study is based on a small sample size of only 65 Mexican-American individuals. Further studies using larger cohorts are warranted. Our data identified several rare functional variants in antidepressant drug response in MDD patients. These have the potential to serve as genetic markers for predicting drug response. ClinicalTrials.gov NCT00265291. ClinicalTrials.gov NCT00265291. Moderate to vigorous physical activity (MVPA) can help to prevent depression, but identification of the most important psycho-biological pathways involved is
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