https://www.selleckchem.com/pr....oducts/e7766-diammon
The concentration of Ang2 in CSDH fluid was significantly higher than that in the serum or CSF and also higher than that of Ang1 in CSDH fluid. Tie2, PI3-kinase, Akt, mTOR, GβL, p70S6K, eIF-4E were detected in all cases. In addition, Tie2, Akt and mTOR were localized in the endothelial cells of vessels within CSDH outer membrane. Our data suggest that Ang2, while not Ang1, in CSDH fluid promotes angiogenesis in endothelial cells through the Tie2 receptor. The Ang2/Tie2 signaling pathway might therefore be a useful therapeu
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