https://www.selleckchem.com/pr....oducts/namodenoson-c
Barrier disruption and an excessive immune response in keratinocytes are now considered to have important roles in the pathophysiology of atopic dermatitis (AD). Furthermore, disturbed keratinocyte differentiation is considered to underlie AD. ΔNp63, a p53-like transcription factor, is a major regulator of keratinocyte differentiation. However, the functional significance of ΔNp63 in AD has not been clarified. In this study, we aimed to investigate the influence of the type 2 inflammatory environment on ΔNp63 expression and A
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