https://www.selleckchem.com/products/cx-5461.html
While sentinel lymph node (SLN) biopsy is typically offered to patients with primary cutaneous melanomas (PCMs) of ≥1mm depth, not all SLNs are positive using this cut-off. To ascertain whether this was genetically regulated, genetic analysis was performed using an augmented enrichment-based next-generation DNA and RNA sequencing assay in SLN- [Group 1, n=8, mean depth 1.3mm] and SLN+ PCMs [Controls, Group 2, n=4, mean depth 1.4mm]. Group 1 Mean number of mutations was 21 (range 3-48) with most frequent mutations in NF1 (75%) followed b
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