https://www.selleckchem.com/pr....oducts/smoothened-ag
Thus, this assay is an invaluable tool in the study of SHM and Ig diversification.The accumulation of unfolded proteins within the endoplasmic reticulum (ER), caused by any stress condition, triggers the unfolded protein response (UPR) through the activation of specialized sensors. UPR attempts first to restore homeostasis; but if damage persists the signaling induces apoptosis. There is increasing evidence that sustained and unresolved ER stress contributes to many pathological conditions including neurodegenerative
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