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, RBC-NOS), that has prospective effects from the vascular smooth muscle tissue. The actual properties of RBCs, including their habit of form three-dimensional structures in low shear flow (i.e., aggregation) and their particular ability to elongate in large shear circulation (for example., deformability), are only recently becoming viewed as mechanotransductive processes, with serious effects on vascular reactivity and tissue perfusion. Present advance
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