https://www.selleckchem.com/pr....oducts/FK-506-(Tacro
It was found that both the basicity and molecular size of the anion play key roles in the formation of the phosphonium ylide. In the extreme case of [P66614][4-Triaz] only half of the reacted product was the desired carbamate at 60 °C. Although there is a significant amount of the carboxyl product formed, the carbamate is kinetically favored.Prediction of skin absorption and local bioavailability from topical formulations remains a difficult task. An important challenge in forecasting topical bioavailability is the limited i
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