https://www.selleckchem.com/pr....oducts/guanidine-thi
This investigation is part of the prospective observational PA-COVID-19 study. Patients responded to initiation of invasive high PEEP ventilation with markedly improved oxygenation, which was accompanied by reduced pulmonary opacities within 6h of mechanical ventilation. Decremental PEEP trials confirmed the need for high PEEP (17.9 (SD ± 3.9) mbar) for optimal oxygenation, while driving pressures remained low. Prone positioning substantially increased oxygenation ( 0.01). In early COVID-19 ARDS, substantial PEEP value
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