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07 ± 0.13 µg / mL) in comparison with the reference drug doxorubicin that has (IC50 = 2.79 ± 0.07 µg / mL). Then compound 5d subjected to further studies such as cell cycle analysis and apoptosis. Apoptosis was confirmed by the up-regulation of Bax, downregulation of Bcl-2, and the increase of the caspase 3/7percentage. Conclusion Insertion of pyrazole, oxadiazole and, quinazoline moieties with 2-thiohydantoin moiety led to the enhancement of its anti-proliferative activity. Hence they can be used as anticancer agents.As a unique and pl
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