https://gsk1838705ainhibitor.c....om/cross-talk-in-bet
We show that short hairpin RNA-mediated SRA silencing substantially improves the immunogenicity of DCs that have grabbed chaperone vaccines made to target melanoma (i.e., hsp110-gp10 and breast cancer (i.e., hsp110-HER/Neu-ICD). SRA downregulation results in heightened activation of antigen-specific T cells and increased CD8+ T cell-dependent tumor inhibition. Additionally, small interfering RNA (siRNA) complexed with the biodegradable, biocompatible chitosan as a carrier can efficiently decrease SRA
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