https://www.selleckchem.com/pr....oducts/mps1-in-6-com
Mutational load was lower for young-onset tumours, and a higher proportion of these mutations were C A mutations, but a lower proportion were C T mutations compared to older-onset tumours. The most common mutational signatures identified in both age groups were signatures 1 and 3 from the COSMIC database. Signatures resembling COSMIC signatures 2 and 13 were observed among both age groups. We identified a class of tumours with a unique combination of signatures that may be associated with young age of onset. CONC
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