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008, OR=2.53, 95% CI=1.27-5.04; P=0.001, OR=1.98, 95% CI=1.31-3.00, respectively). There was a significant association between FOXP3 rs3761548 variant and female MS patients. The serum IL-35 level was significantly higher in MS patients (1372 [575-2192] pg/mL) compared to healthy controls (604 [454-696] pg/mL) (P0.0001). No significant differences were found between the different FOXP3 genotypes and EDSS score (P=0.73. The FOXP3rs3761548 gene variant may influence the genetic susceptibility to MS rather than affecting its course, s
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