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Natural ADHD Medication Alternatives There are many supplements and natural remedies that claim to treat ADHD. It's important to remember that these treatments aren't controlled by the FDA, and may interact with other medications or trigger adverse side effects. Pycnogenol, a plant-based extract, has proven promising to alleviate ADHD symptoms in some studies. It is believed to improve cognitive function and reduces restlessness. Nootropics Many people who are diagnosed with ADHD have discovered that holistic t