https://barasertibinhibitor.co....m/early-life-outcome
Analyzing 2,935 variations in the thiopurine cytotoxicity-based assay, we identified 17 extra deposits where variations altered NUDT15 task without influencing protein security. We identified structural elements crucial to NUDT15 stability and/or catalytical activity with single amino acid resolution. Functional impacts for NUDT15 alternatives accurately predicted toxicity threat alleles in patients treated with thiopurines with far superior sensitiveness and specificit
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