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The mcr-positive variant showed significantly higher phenotypic colistin resistance with MIC between 16 µg/mL and 128 µg/mL (p less then 0.001). Over 85% of colistin-resistant isolates showed MDR phenomena.Conclusions The emergence of the clinical MDR pathogens with resistance to a highly selective drug may lead to a lack of treatment options for the infectious diseases and spread of infection to the unaffected cohorts.IntroductionNuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key role in diverse gene
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