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Lastly, the questionnaire was completed in Phase IV by cognitive interviewing of five new chronic sialadenitis patients; ensuring ease of understanding and clarity. Patients identified 15 domains of QoL impacted by chronic sialadenitis, divided into three sub-scales physical symptoms, psychosocial symptoms, and activity restriction. These domains provided the basis for creation of a 22-item PRO questionnaire, with a Likert-type response scale. Clinical application of the novel questionnaire produced by this study will allow for a patie
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