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This study aims at exploring and quantifying multiple types of adverse events (AEs) experienced by patients during cancer treatment. A novel longitudinal score to evaluate the Multiple Overall Toxicity (MOTox) burden is proposed. The MOTox approach investigates the personalised evolution of high overall toxicity (high-MOTox) during the treatment. Retrospective analysis of the MRC-BO06/EORTC-80931 randomised controlled trial for osteosarcoma. International multicentre population-based study. A total of 377 patients with resectable high-g
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